Human T-lymphotropic virus type I: new risk for Chilean population.
نویسندگان
چکیده
Human T-lymphotropic virus type I (HTLV-I), a human retrovirus, has been etiologically associated with adult T-cell leukemia (ATL) and with a demyelinating neurologic disorder termed tropical spastic paraparesia (TSP) or HTLV-I-associated myelopathy (HAM), and has raised concern that spread of this virus by blood transfusion may result in disease among recipients.’ HTLV-I is highly endemic in Japan and the Caribbean where different prevalence rates have been reported in donors or in the general population.4ss In 1989, Cartier et a1 reported in a large group of Chilean patients with slowly progressive spastic paraparesis of unknown etiology, the presence of antibodies to HTLV-I in serum and cerebrospinal fluid. This was the first report of HTLV-I in a population from a temperate climate region.’ We evaluated the seroprevalence of HTLV-I antibodies in 954 healthy blood donors in Santiago, Chile. Donor samples were tested by two different methods, Serodia HTLV-I Passive Particle Agglutination Test (Tokyo, Japan) and Abbott HTLV-I EIA (Chicago, IL). The reactive samples were studied by Western blot Dupont in the national reference AIDS laboratory at the Public Health Institute in Santiago. Our results were further analyzed by Western blot and radio immunoprecipitation assay in the HTLV-I Research and Development Department, Abbott Laboratories, and confirmed (Table 1).
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To investigate candidate genes that influence the risk of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed 6 single nucleotide polymorphisms (SNP) in the interleukin-10 (IL-10) promoter region. METHODS: 280 cases of HAM/TSP patients and 255 HTLV-I seropositive asymptomatic carriers (HCs) from Kagoshima, Japan were studied. All subjects gave written informed conse...
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عنوان ژورنال:
- Blood
دوره 78 3 شماره
صفحات -
تاریخ انتشار 1991